Sanctuary follows the exploits of Dr. Helen Magnus (Amanda Tapping) and her quest to protect what most people would consider monsters. "The Sanctuary" serves as a safe haven for these "Abnormals." She is aided in her quest by her reluctant protégé Will Zimmerman (Robin Dunne); her intrepid, if somewhat reckless, daughter Ashley (Emilie Ullerup); the talkative geek Henry Foss (Ryan Robbins), a computer and security expert; and her taciturn Neanderthal-like unnamed assistant (a Bigfoot), sometimes called "Big Guy" (Christopher Heyerdahl).